Science Today

Wirelessy Powered Brain Implant Could Treat Depression


A wirelessly powered implant the size of a grain of rice can electrically stimulate the brains of mice as the rodents do what they please. The new gadget could help scientists better understand and treat mental health disorders such as depression, according to a new study.

The human brain is the most powerful computer known, an extraordinary assembly of living electrical circuits. To gain greater understanding of how the human brain works — and how to fix any problems with it — neuroscientists would like to electrically stimulate the brains of simpler animals as they scurry around, carry out tasks and respond to their surroundings.

Tiny, untethered brain-stimulating devices would permit animals to move, behave and react freely during experiments. However, batteries are too heavy and bulky to fit into such small gizmos. Instead, these inventions could be wirelessly powered using magnetic induction, wherein one coil of wire can transmit energy to another coil using magnetic fields.

“Wireless neural stimulation in mice has been demonstrated many times before, and in many of these systems, the mice could freely move over a large area,” said study senior author Ada Poon, an electrical engineer at Stanford University in California.

However, previous wireless brain-stimulating devices were limited by their power-harvesting components. If these parts were small, power was lost if the animals moved away from the spot where the energy was focused, which limited how far the animals could roam. On the other hand, if these parts were large, they were typically too big to be implanted.

Other labs either used bulky devices mounted on the skulls of mice, or used complex arrays of coils paired with sensors to locate the mice and deliver power. “To us that sounded like a lot of work,” Poon told Live Science. “We were ‘lazy.’ The ‘laziness’ led us to be more creative.”

Now the researchers have created implantable wirelessly powered brain-stimulating devices by essentially using the mouse’s body to help collect energy.

“Surprisingly, it works,” Poon said. “Engineers tend to think of complex solutions, but sometimes if we back off a bit and think out of the box, we might be able to come up with some crazy but workable solutions that are simpler.”

The roughly cylindrical device is about 2 millimeters wide, 3 mm long, and 20 mm in weight, making it about 100 times smaller and lighter than previous devices. “We like to compare the size with a grain of rice of the slightly thicker sort,” Poon said.

The bodies of the mice are not used to absorb energy, the researchers said. Rather, the mouse bodies interact with surrounding magnetic fields, helping focus energy like a lens from the transmitter to the receiver in the implant.

About one-thousandth of the energy transmitted at the mice gets absorbed by the devices, an efficiency comparable to previous systems, the researchers said. “We achieve these efficiencies, however, without limiting the area of coverage or requiring large head-mounted antennae,” Poon added.

The scientists could power the implant as the mice roamed across a 6.3-inch-wide (16 centimeters) chamber lined with a magnetic lattice. The device was implanted in a region of the mouse brain known the infralimbic cortex, which is implicated in animal models of depression and anxiety.

“This will open the door to a range of new experiments to better understand and treat mental health disorders such as depression,” Poon said. “In addition, since there is no wire and no protruding structure coming out of the animals, it will allow experiments with multiple animals in the same space to better understand social interaction — in the treatment of chronic pain and mental disorders, for example.”

Southern Ocean removing carbon dioxide from atmosphere more efficiently

The ARSV Laurence M. Gould in the Southern Ocean. Credit: Colm Sweeney/ CIRES & NOAA
The ARSV Laurence M. Gould in the Southern Ocean.
Credit: Colm Sweeney/ CIRES & NOAA

Scientists compile densest carbon data set in Antarctic waters

September 10, 2015
American Geophysical Union
Since 2002, the Southern Ocean has been removing more of the greenhouse gas carbon dioxide from the atmosphere, according to two new studies.

Since 2002, the Southern Ocean has been removing more of the greenhouse gas carbon dioxide from the atmosphere, according to two new studies.

These studies make use of millions of ship-based observations and a variety of data analysis techniques to conclude that that the Southern Ocean has increasingly taken up more carbon dioxide during the last 13 years. That follows a decade from the early 1990s to 2000s, where evidence suggested the Southern Ocean carbon dioxide sink was weakening. The new studies appear today in the American Geophysical Union journal Geophysical Research Letters and the AAAS journal Science.

The global oceans are an important sink for human-released carbon dioxide, absorbing nearly a quarter of the total carbon dioxide emissions every year. Of all ocean regions, the Southern Ocean below the 35th parallel south plays a particularly vital role. “Although it comprises only 26 percent of the total ocean area, the Southern Ocean has absorbed nearly 40 percent of all anthropogenic carbon dioxide taken up by the global oceans up to the present,” says David Munro, a scientist at the Institute of Arctic and Alpine Research (INSTAAR) at the University of Colorado Boulder, and an author on the GRL paper.

The GRL paper focuses on one region of the Southern Ocean extending from the tip of South America to the tip of the Antarctic Peninsula. “The Drake Passage is the windiest, roughest part of the Southern Ocean,” says Colm Sweeney, lead investigator on the Drake Passage study, co-author on both the GRL and Science papers, and a CIRES scientist working in the NOAA Earth System Research Laboratory in Boulder, Colorado. “The critical element to this study is that we were able to sustain measurements in this harsh environment as long as we have–both in the summer and the winter, in every year over the last 13 years. This data set of ocean carbon measurements is the densest ongoing time series in the Southern Ocean.”

The team was able to take these long-term measurements by piggybacking instruments on the Antarctic Research Supply Vessel Laurence M. Gould. The National Science Foundation-supported Gould, which makes nearly 20 crossings of the Drake Passage each year, transporting people and supplies to and from Antarctic research stations. For over 13 years, it’s taken chemical measurements of the atmosphere and surface ocean along the way.

By analyzing more than one million surface ocean observations, the researchers could tease out subtle differences between the carbon dioxide trends in the surface ocean and the atmosphere that suggest a strengthening of the carbon sink. This change is most pronounced in the southern half of the Drake Passage during winter. Although the researchers aren’t sure of the exact mechanism driving these changes, “it’s likely that winter mixing with deep waters that have not had contact with the atmosphere for several hundred years plays an important role,” says Munro.

The Science paper, led by Peter Landschützer at the ETH Zurich, takes a more expansive view of the Southern Ocean. This study uses two innovative methods to analyze a dataset of surface water carbon dioxide spanning almost three decades and covering all of the waters below the 35th parallel south. These data–including Sweeney and Munro’s data from the Drake Passage–also show that the surface water carbon dioxide is increasing slower than atmospheric carbon dioxide, a sign that the Southern Ocean as a whole is more efficiently removing carbon from the atmosphere. These results contrast with previous findings that showed that the Southern Ocean carbon dioxide sink was stagnant or weakening from the early 1990s to the early 2000s.

In addition to the Drake Passage measurements, the Science paper uses datasets that represent a significant international collaboration, including carbon dioxide sampling from NOAA’s Ship of Opportunity Program. This program, led by Rik Wanninkhof of NOAA’s Atlantic Oceanographic and Meteorological Laboratory (AOML) who is also a co-author of the Science paper, is the world’s largest coordinated carbon dioxide sampling operation. Despite all these efforts, the Southern Ocean remains undersampled. “Given the importance of the Southern Ocean to the global oceans’ role in absorbing atmospheric carbon dioxide, these studies suggest that we must continue to expand our measurements in this part of the world despite the challenging environment,” says Sweeney.


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